{"id":695,"date":"2022-09-16T21:20:41","date_gmt":"2022-09-16T21:20:41","guid":{"rendered":"http:\/\/www.cbe.iastate.edu\/vigil\/?p=695"},"modified":"2023-04-27T20:13:43","modified_gmt":"2023-04-27T20:13:43","slug":"biomadeproject","status":"publish","type":"post","link":"https:\/\/www.cbe.iastate.edu\/vigil\/uncategorized\/biomadeproject\/","title":{"rendered":"Fermentation scale-up research jumps the lab-to-production gap"},"content":{"rendered":"

A group of Iowa State researchers, led by\u00a0Rodney Fox<\/strong>, CoMFRE executive director, is collaborating with Cargill and Genomatica to scale-up fermentation processes. The award was\u00a0announced this week at the White<\/a>\u00a0House<\/a>\u00a0Summit on the National Biotechnology and Biomanufacturing Initiative. The project starts by perfecting fermentation techniques in the small laboratory scale. \u201cWhat makes simulation and scale-up of bioreactors difficult is the fact that microorganisms, which function as small chemical factories, are heavily influenced by both the microenvironment that they are in, and also the microenvironment\u2019s trajectory, or history,\u201d says\u00a0Dennis Vigil<\/strong>, CoMFRE affiliate and professor of chemical and biological engineering. \u201cAs the bioreactor size increases the heterogeneity of microenvironments increases, which makes prediction of the overall performance of the bioreactor more difficult. This is the problem we are trying to address by first understanding how microorganisms perform in a uniform homogeneous environment.\u201d Both Fox, who is also Hershel B. Whitney Professor, Global Initiatives, and Anson Marston Distinguished Professor in Engineering, and Vigil specialize in multiphase reactor design and analysis. Ted Heindel,\u00a0<\/strong>CoMFRE center director, Bergles Professor in Thermal Science and University Professor of mechanical engineering, and\u00a0Alberto Passalacqua<\/strong>, CoMFRE associate director and associate professor of mechanical engineering, bring expertise in measurement and computational fluid dynamics. And\u00a0Zengyi Shao<\/strong>, associate professor of chemical and biological engineering, leverages her expertise in the manipulation of microbes that drive the fermentation process. Cargill and Genomatica will then team up to move the process to large-scale production of a new generation bio-based intermediate chemical product used by many industries. It will be produced in a new facility at Cargill\u2019s Eddyville, Iowa, operation. A portion of $2.5 million funding for the project is from BioMADE, a manufacturing innovation institute supported by the Department of Defense that works to advance research directed at the manufacturing of bio-based products. Iowa State is a governing member of BioMADE.<\/p>\n

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A group of Iowa State researchers, led by\u00a0Rodney Fox, CoMFRE executive director, is collaborating with Cargill and Genomatica to scale-up fermentation processes. The award was\u00a0announced this week at the White\u00a0House\u00a0Summit on the National Biotechnology and Biomanufacturing Initiative. The project starts by perfecting fermentation techniques in the small laboratory scale. \u201cWhat makes simulation and scale-up of […]<\/p>\n","protected":false},"author":2040,"featured_media":924,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"off","_et_pb_old_content":"A group of Iowa State researchers, led by\u00a0Rodney Fox<\/strong>, CoMFRE executive director, is collaborating with Cargill and Genomatica to scale-up fermentation processes. The award was\u00a0announced this week at the White<\/a>\u00a0House<\/a>\u00a0Summit on the National Biotechnology and Biomanufacturing Initiative. The project starts by perfecting fermentation techniques in the small laboratory scale. \u201cWhat makes simulation and scale-up of bioreactors difficult is the fact that microorganisms, which function as small chemical factories, are heavily influenced by both the microenvironment that they are in, and also the microenvironment\u2019s trajectory, or history,\u201d says\u00a0Dennis Vigil<\/strong>, CoMFRE affiliate and professor of chemical and biological engineering. \u201cAs the bioreactor size increases the heterogeneity of microenvironments increases, which makes prediction of the overall performance of the bioreactor more difficult. This is the problem we are trying to address by first understanding how microorganisms perform in a uniform homogeneous environment.\u201d Both Fox, who is also Hershel B. Whitney Professor, Global Initiatives, and Anson Marston Distinguished Professor in Engineering, and Vigil specialize in multiphase reactor design and analysis. Ted Heindel,\u00a0<\/strong>CoMFRE center director, Bergles Professor in Thermal Science and University Professor of mechanical engineering, and\u00a0Alberto Passalacqua<\/strong>, CoMFRE associate director and associate professor of mechanical engineering, bring expertise in measurement and computational fluid dynamics. And\u00a0Zengyi Shao<\/strong>, associate professor of chemical and biological engineering, leverages her expertise in the manipulation of microbes that drive the fermentation process. Cargill and Genomatica will then team up to move the process to large-scale production of a new generation bio-based intermediate chemical product used by many industries. It will be produced in a new facility at Cargill\u2019s Eddyville, Iowa, operation. A portion of $2.5 million funding for the project is from BioMADE, a manufacturing innovation institute supported by the Department of Defense that works to advance research directed at the manufacturing of bio-based products. Iowa State is a governing member of BioMADE.\r\n

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