HJ Yoon*, A Shanker*, Y Wang, M Kozminsky, Q Jin, N Palanisamy, ML Burness, E Azizi, DM Simeone, MS Wicha, J Kim, S Nagrath. “Tunable Thermal‐Sensitive Polymer–Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.” Advanced materials 28.24 (2016): 4891-4897. *denotes equal contribution
Abstract: A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.